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Title:
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The journal of infectious diseases, Vol 198 N°2
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Authors:
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Louisa E. Chapman, Author
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Material Type:
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Serial check-in : printed text
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Published date :
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07/15/2008
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Publication Date:
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2008
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Size:
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couv. ill. coul. / 27 cm
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Languages:
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English
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Original Language:
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English
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Class number:
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616.979
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Descriptors:
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616.979 Sida
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Keywords:
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Virus, traitement, soins, vaccins, prévention, sensibilisation.
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Abstract:
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Iron plus folate supplementation increases mortality and morbidity among children in areas of malaria endemicity in Africa, but the effects of supplementation on pregnant women in malaria-endemic areas remain unclear. In northeastern Tanzania, where malaria and iron deficiency are common, we found that placental malaria was less prevalent (8.5% vs. 47.3% of women; P < .0001) and less severe (median parasite density, 4.2% vs. 6.3% of placental red blood cells; P = .04) among women with iron deficiency than among women with sufficient iron stores, especially during the first pregnancy. Multivariate analysis revealed that iron deficiency (P < .0001) and multigravidity (P = .002) significantly decreased the risk of placental malaria. Interventional trials of iron and folate supplementation during pregnancy in malaria-endemic regions in Africa are urgently needed to ascertain the benefits and risks of this intervention.
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Link for e-copy:
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https://academic.oup.com/jid/issue/198/2
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