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Title:
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The journal of infectious diseases, Vol 198 N°8
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Authors:
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Louisa E. Chapman, Author
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Material Type:
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Serial check-in : printed text
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Published date :
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10/15/2008
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Publication Date:
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2008
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Size:
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couv. ill. coul. / 27 cm
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Languages:
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English
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Original Language:
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English
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Class number:
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616.979
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Descriptors:
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616.979 Sida
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Keywords:
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Vih, bacterie, traitement, antirétroviraux, soins, prise en charge, sensibilisation, prévention, vaccin.
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Abstract:
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We examined the emergence of CXCR4 (i.e., X4) tropism in 67 male human immunodeficiency virus type 1 (HIV-1) seroconverters from the Multicenter AIDS Cohort Study (MACS) who were selected to reflect the full spectrum of rates of HIV-1 disease progression. A mean of 10 serial samples per donor were evaluated by a laboratory-validated, commercially available assay to determine phenotypic coreceptor use.Atotal of 52% of men had dual- or mixed-tropic HIV-1 detected at 1 or more of the time points tested. Use of X4 by HIV-1 was detected more frequently among men who developed AIDS (defined as a CD4+ T cell count of <200 cells/µL and/or an AIDS-defining illness) ⩽11 years after seroconversion thanamongthosewhodid not (P = .005), as well asamong men who exhibited a total T cell count decline (i.e., a CD3+ inflection point), compared with those who did not (P = .03). Formen in whom both X4 virus and an inflection point were detected, emergence of X4 virus preceded the inflection point by a median of 0.83 years. The median CD4+ T cell count at first detection of X4 viruses before the onset of AIDS was 475 cells/µL. We conclude that HIV-1 variants that used X4 frequently emerged at high CD4+ T cell counts and may contribute to the decrease in T cell numbers during late HIV-1 infection.
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Link for e-copy:
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https://academic.oup.com/jid/issue/198/8
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